ABSTRACT
Systemic Lupus Erythematosus is an autoimmune disease characterized by the production of a heterogeneous group of autoantibodies: unavoidable element for diagnosis, prognosis and therapeutic monitoring. The aim of this study was to establish the profile of some autoantibodies in Moroccan lupus patients. This is a prospective study conducted over six months, in the Immunology Laboratory of the Faculty of Pharmacy and Medicine of the University Hassan II of Casablanca, including 30 patients with Systemic lupus erythematosus. The average age of our patients was 34, 6 years, with a female predominance [sex-ratio: 0, 2] Clinical signs were polymorphic, dominated by hematological [25 cases], skin [22 cases], rheumatological [21 cases] and kidney disorders [8 cases]. Immunologically, anti-nuclear antibodies were positive in 77% of cases, and anti-dsDNA in 73, 9% of cases. For soluble anti-antigen antibodies, they were dominated by anti SSA antibodies [52%]. The involvement of anti-dsDNA and anti-SSA in disease activity was deducted, hence the crucial importance of systematic research of these autoantibodies for regular monitoring of lupus patients preventing the occurrence of systemic manifestations
ABSTRACT
In the past decade in Morocco, there has been a reactivation of zoonotic cutaneous leishmaniasis [ZCL] foci with an unusual long outbreak episode. The aims of this review article were to update our knowledge of this disease in Morocco, to compare the situation with that prevailing in the other countries of the Maghreb region and to highlight factors that could be responsible for the current situation. The data indicate a global increase of ZCL incidence in the other Maghreb countries. Several factors could be influencing this increase but most of them will depend on human activities. On the other hand, ZCL is particularly sensitive to climate changes acting on the vector and the reservoir. An analysis of prevention strategies against the disease in Morocco and the other Maghreb countries highlights the need for integrated regional control measures in all the countries of the region